From Clinical OMICS.com by Mike May
From Mendelian disorders to COVID-19, academic and industrial scientists use these nucleic acids to help diagnose diseases.
Molecular methods of diagnosing diseases promise fast and accurate approaches for an array of conditions. While many molecular diagnostics look for mutations in DNA, an increasing number analyze a sample’s RNA, and those are explored here. Manufacturers offer a variety of RNA-based diagnostics, and academic scientists continue to explore new approaches to using these molecules for medical analyses.
“One key benefit to RNA-based diagnostics is that there is an abundance of RNA in a cell as compared to DNA, which gives these tests a high level of sensitivity,” says Damon Getman, director, scientific affairs at diagnostic and medical imaging company Hologic. That sensitivity played a key role in developing a diagnostic for the sexually transmitted bacterium Mycoplasma genitalium. This bacterium “is the smallest characterized free-living organism capable of self-replication, and it is extremely difficult to grow in culture,” Getman explains. “In the early 2000’s, Hologic scientists collaborated closely with academic clinical investigators, providing research-use-only reagents for molecular detection of M. genitalium.”
From Clinical OMICS.com by Mike May
From Mendelian disorders to COVID-19, academic and industrial scientists use these nucleic acids to help diagnose diseases.
Molecular methods of diagnosing diseases promise fast and accurate approaches for an array of conditions. While many molecular diagnostics look for mutations in DNA, an increasing number analyze a sample’s RNA, and those are explored here. Manufacturers offer a variety of RNA-based diagnostics, and academic scientists continue to explore new approaches to using these molecules for medical analyses.
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From Clinical OMICS.com by Mike May
From Mendelian disorders to COVID-19, academic and industrial scientists use these nucleic acids to help diagnose diseases.
Molecular methods of diagnosing diseases promise fast and accurate approaches for an array of conditions. While many molecular diagnostics look for mutations in DNA, an increasing number analyze a sample’s RNA, and those are explored here. Manufacturers offer a variety of RNA-based diagnostics, and academic scientists continue to explore new approaches to using these molecules for medical analyses.
Related Posts
Worm’s radical transformation shows metamorphosis can change the functions of cells
RNA sequencing reveals functional chimeric mRNAs in mammalian immunity
Atlas of the brain’s striatum could guide researchers to new drug treatments
Immune cells offer insights on billion-dollar virus
A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction
Dietary oxidized plant sterol shifts macrophage state to fuel aortic inflammation
Unlocking the past – new method helps gain insights into old tissue
Novel AI model trained on RNA-Seq data accurately detects key gene mutations and predicts biomarkers across 32 cancer types
Transcriptomic aging clock reveals age-related molecular patterns in opioid dependence
RNA sequencing helps predict stem cell transplant benefit in pediatric AML
Protein ‘switch’ determines whether liposarcoma cells will become aggressive
Precursor tRNAs sense temperature changes: heat stress-induced capped pre-tRNAs suppress protein synthesis
Ketamine increases neuroplasticity in female mice but not in males
Somatic mutations linked to vascular damage in progeria
Scientists map dormant cancer cells’ hideouts, opening new targets for treatment
Soluble signals released by neighboring cells direct how the human kidney is built
Genetics influence how cancer arises – and how it evolves
RNA-based testing uncovers extraordinary diversity in mutations driving lung cancer
Study offers new insights into why ex-smokers remain at elevated risk of lung disease
Learning the grammar of gene regulation
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