RNA modifications – an overview
The field of epigenetics is branching down many new and exciting avenues. One of these avenues is the area of RNA modification research. Recent advancements in the development of RNA modification detection and sequencing methods eg miCLIP has meant that it is becoming easier and faster to discover new modifications and map them to different species of RNA within any cell type or model organism. The advancements in this technology lead to a boom in the number of known RNA modifications. Currently, there are over 100 known RNA chemical modifications including m6A, m1A, and m2,2G. You find these on mRNA, tRNAs, rRNAs and other non-coding RNAs including miRNAs. Each of these modifications also has its own functions including RNA structure, export, stability, and mRNA splicing. The future is bright for this field of research; there is still much to uncover about the function of some of these new exciting modifications.