from Genetic Engineering News –
Even though its causes have been unclear, premenstrual dysphoric disorder (PMDD) has been described as a severe form of premenstrual syndrome (PMS). Affecting 2–5% of women of reproductive age, PMDD is like PMS in that it follows a predictable, cyclic pattern. Yet PMDD, which is marked by disabling irritability, sadness, and anxiety, is associated with unusual sensitivity to fluctuations in sex hormones. This sensitivity has motivated researchers to focus on PMDD’s potential biological drivers, rather than on psychological or cultural phenomena.
New results from scientists based at the National Institutes of Health (NIH) suggest that PMDD arises from certain molecular mechanisms. These scientists report that they have found that a large gene complex shows a conspicuous difference in its response to ovarian steroids.
“In this study, lymphoblastoid cell line cultures (LCLs) from women with PMDD and asymptomatic controls were compared via whole-transcriptome sequencing (RNA-seq) during untreated (ovarian steroid-free) conditions and following hormone treatment,” wrote the article’s authors. “The women with PMDD manifested ovarian steroid-triggered behavioral sensitivity during a hormone suppression and addback clinical trial, and controls did not, leading us to hypothesize that women with PMDD might differ in their cellular response to ovarian steroids.”
The expression of the Extra Sex Combs/Enhancer of Zeste, or ESC/E(Z), gene network was found to be systematically disturbed in PMDD. [Peter Schmidt, M.D./NIMH; David Goldman, M.D./NIAAA]
(read more at Genetic Engineering News…)
Dubey N, Hoffman JF, Schuebel K, Yuan Q, Martinez PE, Nieman LK, Rubinow DR, Schmidt PJ, Goldman D. (2017) The ESC/E(Z) complex, an effector of response to ovarian steroids, manifests an intrinsic difference in cells from women with premenstrual dysphoric disorder. Molecular Psychiatry [Epub ahead of print]. [abstract]
from Genetic Engineering News –
Even though its causes have been unclear, premenstrual dysphoric disorder (PMDD) has been described as a severe form of premenstrual syndrome (PMS). Affecting 2–5% of women of reproductive age, PMDD is like PMS in that it follows a predictable, cyclic pattern. Yet PMDD, which is marked by disabling irritability, sadness, and anxiety, is associated with unusual sensitivity to fluctuations in sex hormones. This sensitivity has motivated researchers to focus on PMDD’s potential biological drivers, rather than on psychological or cultural phenomena.
New results from scientists based at the National Institutes of Health (NIH) suggest that PMDD arises from certain molecular mechanisms. These scientists report that they have found that a large gene complex shows a conspicuous difference in its response to ovarian steroids.
The expression of the Extra Sex Combs/Enhancer of Zeste, or ESC/E(Z), gene network was found to be systematically disturbed in PMDD. [Peter Schmidt, M.D./NIMH; David Goldman, M.D./NIAAA]
(read more at Genetic Engineering News…)
Dubey N, Hoffman JF, Schuebel K, Yuan Q, Martinez PE, Nieman LK, Rubinow DR, Schmidt PJ, Goldman D. (2017) The ESC/E(Z) complex, an effector of response to ovarian steroids, manifests an intrinsic difference in cells from women with premenstrual dysphoric disorder. Molecular Psychiatry [Epub ahead of print]. [abstract]
Related Posts
RNA sequencing reveals functional chimeric mRNAs in mammalian immunity
Atlas of the brain’s striatum could guide researchers to new drug treatments
Immune cells offer insights on billion-dollar virus
A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction
Dietary oxidized plant sterol shifts macrophage state to fuel aortic inflammation
Unlocking the past – new method helps gain insights into old tissue
Novel AI model trained on RNA-Seq data accurately detects key gene mutations and predicts biomarkers across 32 cancer types
Transcriptomic aging clock reveals age-related molecular patterns in opioid dependence
RNA sequencing helps predict stem cell transplant benefit in pediatric AML
Protein ‘switch’ determines whether liposarcoma cells will become aggressive
Precursor tRNAs sense temperature changes: heat stress-induced capped pre-tRNAs suppress protein synthesis
Ketamine increases neuroplasticity in female mice but not in males
Somatic mutations linked to vascular damage in progeria
Scientists map dormant cancer cells’ hideouts, opening new targets for treatment
Soluble signals released by neighboring cells direct how the human kidney is built
Genetics influence how cancer arises – and how it evolves
RNA-based testing uncovers extraordinary diversity in mutations driving lung cancer
Study offers new insights into why ex-smokers remain at elevated risk of lung disease
Learning the grammar of gene regulation
New findings could transform new treatment for rare brain tumor astroblastoma
from Genetic Engineering News –
Even though its causes have been unclear, premenstrual dysphoric disorder (PMDD) has been described as a severe form of premenstrual syndrome (PMS). Affecting 2–5% of women of reproductive age, PMDD is like PMS in that it follows a predictable, cyclic pattern. Yet PMDD, which is marked by disabling irritability, sadness, and anxiety, is associated with unusual sensitivity to fluctuations in sex hormones. This sensitivity has motivated researchers to focus on PMDD’s potential biological drivers, rather than on psychological or cultural phenomena.
New results from scientists based at the National Institutes of Health (NIH) suggest that PMDD arises from certain molecular mechanisms. These scientists report that they have found that a large gene complex shows a conspicuous difference in its response to ovarian steroids.
The expression of the Extra Sex Combs/Enhancer of Zeste, or ESC/E(Z), gene network was found to be systematically disturbed in PMDD. [Peter Schmidt, M.D./NIMH; David Goldman, M.D./NIAAA]
(read more at Genetic Engineering News…)
Dubey N, Hoffman JF, Schuebel K, Yuan Q, Martinez PE, Nieman LK, Rubinow DR, Schmidt PJ, Goldman D. (2017) The ESC/E(Z) complex, an effector of response to ovarian steroids, manifests an intrinsic difference in cells from women with premenstrual dysphoric disorder. Molecular Psychiatry [Epub ahead of print]. [abstract]
Related Posts
RNA sequencing reveals functional chimeric mRNAs in mammalian immunity
Atlas of the brain’s striatum could guide researchers to new drug treatments
Immune cells offer insights on billion-dollar virus
A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction
Dietary oxidized plant sterol shifts macrophage state to fuel aortic inflammation
Unlocking the past – new method helps gain insights into old tissue
Novel AI model trained on RNA-Seq data accurately detects key gene mutations and predicts biomarkers across 32 cancer types
Transcriptomic aging clock reveals age-related molecular patterns in opioid dependence
RNA sequencing helps predict stem cell transplant benefit in pediatric AML
Protein ‘switch’ determines whether liposarcoma cells will become aggressive
Precursor tRNAs sense temperature changes: heat stress-induced capped pre-tRNAs suppress protein synthesis
Ketamine increases neuroplasticity in female mice but not in males
Somatic mutations linked to vascular damage in progeria
Scientists map dormant cancer cells’ hideouts, opening new targets for treatment
Soluble signals released by neighboring cells direct how the human kidney is built
Genetics influence how cancer arises – and how it evolves
RNA-based testing uncovers extraordinary diversity in mutations driving lung cancer
Study offers new insights into why ex-smokers remain at elevated risk of lung disease
Learning the grammar of gene regulation
New findings could transform new treatment for rare brain tumor astroblastoma
Stay Connected
Submit a Post to the Blog
Recent Posts
Subscribe to the RNA-Seq Blog
RNA-Seq Products & Services