Researchers in England have identified a large group of genes that may be significant for better testing and treatment of prostate cancer.
Glycan sugar groups on the surface of prostate cancer cells were found to react to changes in testosterone levels that help the disease grow and spread, and may prove to be a good target for treatment, researchers at Newcastle University report in a study published in the journal EBioMedicine.
The researchers used RNA sequencing on a prostate cancer cell line and seven prostate cancer patients to identify 700 clinically relevant genes affected by testosterone.
Researchers watched for responses to androgen stimulation in cell cultures, and androgen deprivation in patients, finding the glycan groups responded and, when expressed in cancer cells, contributed to the survival of prostate cancer cells.
While more research will be needed, researchers say they have been identified as a good target for treatment in breast cancer and immunotherapy targeting glycan groups in neuroblastoma was found in previous research to be successful against the disease.
“Our findings are very significant for future treatments as they identify a new group of molecules in prostate cancer which could be targeted therapeutically,” Dr. Jennifer Munkley, a research associate at the Institute of Genetic Medicine at Newcastle University, said in a press release. “Now we have identified these glycans we will be able to develop strategies to inhibit them and help patients with this condition.”
Source – UPI
[box type=”shadow” align=”alignleft” ]Munkley J, Vodak D, Livermore KE, James K, Wilson BT, Knight B, Mccullagh P, Mcgrath J, Crundwell M, Harries LW, Leung HY, Robson CN, Mills IG, Rajan P, Elliott DJ. (2016)
Glycosylation is an Androgen-Regulated Process Essential for Prostate Cancer Cell Viability. EBioMedicine 8:103-16. [
article][/fusion_text][/fusion_builder_column_inner][/fusion_builder_row_inner][/fusion_builder_column]
from UPI – by Stephen Feller –
Glycan sugar groups are already a target for treatment in breast cancer and neuroblastoma.
Researchers in England have identified a large group of genes that may be significant for better testing and treatment of prostate cancer.
Glycan sugar groups on the surface of prostate cancer cells were found to react to changes in testosterone levels that help the disease grow and spread, and may prove to be a good target for treatment, researchers at Newcastle University report in a study published in the journal EBioMedicine.
The researchers used RNA sequencing on a prostate cancer cell line and seven prostate cancer patients to identify 700 clinically relevant genes affected by testosterone.
Researchers watched for responses to androgen stimulation in cell cultures, and androgen deprivation in patients, finding the glycan groups responded and, when expressed in cancer cells, contributed to the survival of prostate cancer cells.
While more research will be needed, researchers say they have been identified as a good target for treatment in breast cancer and immunotherapy targeting glycan groups in neuroblastoma was found in previous research to be successful against the disease.
“Our findings are very significant for future treatments as they identify a new group of molecules in prostate cancer which could be targeted therapeutically,” Dr. Jennifer Munkley, a research associate at the Institute of Genetic Medicine at Newcastle University, said in a press release. “Now we have identified these glycans we will be able to develop strategies to inhibit them and help patients with this condition.”
Source – UPI
[box type=”shadow” align=”alignleft” ]Munkley J, Vodak D, Livermore KE, James K, Wilson BT, Knight B, Mccullagh P, Mcgrath J, Crundwell M, Harries LW, Leung HY, Robson CN, Mills IG, Rajan P, Elliott DJ. (2016) Glycosylation is an Androgen-Regulated Process Essential for Prostate Cancer Cell Viability. EBioMedicine 8:103-16. [article][/fusion_text][/fusion_builder_column_inner][/fusion_builder_row_inner][/fusion_builder_column]Related Posts
RNA sequencing reveals functional chimeric mRNAs in mammalian immunity
Atlas of the brain’s striatum could guide researchers to new drug treatments
Immune cells offer insights on billion-dollar virus
A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction
Dietary oxidized plant sterol shifts macrophage state to fuel aortic inflammation
Unlocking the past – new method helps gain insights into old tissue
Novel AI model trained on RNA-Seq data accurately detects key gene mutations and predicts biomarkers across 32 cancer types
Transcriptomic aging clock reveals age-related molecular patterns in opioid dependence
RNA sequencing helps predict stem cell transplant benefit in pediatric AML
Protein ‘switch’ determines whether liposarcoma cells will become aggressive
Precursor tRNAs sense temperature changes: heat stress-induced capped pre-tRNAs suppress protein synthesis
Ketamine increases neuroplasticity in female mice but not in males
Somatic mutations linked to vascular damage in progeria
Scientists map dormant cancer cells’ hideouts, opening new targets for treatment
Soluble signals released by neighboring cells direct how the human kidney is built
Genetics influence how cancer arises – and how it evolves
RNA-based testing uncovers extraordinary diversity in mutations driving lung cancer
Study offers new insights into why ex-smokers remain at elevated risk of lung disease
Learning the grammar of gene regulation
New findings could transform new treatment for rare brain tumor astroblastoma
from UPI – by Stephen Feller –
Glycan sugar groups are already a target for treatment in breast cancer and neuroblastoma.
Researchers in England have identified a large group of genes that may be significant for better testing and treatment of prostate cancer.
Glycan sugar groups on the surface of prostate cancer cells were found to react to changes in testosterone levels that help the disease grow and spread, and may prove to be a good target for treatment, researchers at Newcastle University report in a study published in the journal EBioMedicine.
The researchers used RNA sequencing on a prostate cancer cell line and seven prostate cancer patients to identify 700 clinically relevant genes affected by testosterone.
Researchers watched for responses to androgen stimulation in cell cultures, and androgen deprivation in patients, finding the glycan groups responded and, when expressed in cancer cells, contributed to the survival of prostate cancer cells.
While more research will be needed, researchers say they have been identified as a good target for treatment in breast cancer and immunotherapy targeting glycan groups in neuroblastoma was found in previous research to be successful against the disease.
“Our findings are very significant for future treatments as they identify a new group of molecules in prostate cancer which could be targeted therapeutically,” Dr. Jennifer Munkley, a research associate at the Institute of Genetic Medicine at Newcastle University, said in a press release. “Now we have identified these glycans we will be able to develop strategies to inhibit them and help patients with this condition.”
Source – UPI
[box type=”shadow” align=”alignleft” ]Munkley J, Vodak D, Livermore KE, James K, Wilson BT, Knight B, Mccullagh P, Mcgrath J, Crundwell M, Harries LW, Leung HY, Robson CN, Mills IG, Rajan P, Elliott DJ. (2016) Glycosylation is an Androgen-Regulated Process Essential for Prostate Cancer Cell Viability. EBioMedicine 8:103-16. [article][/fusion_text][/fusion_builder_column_inner][/fusion_builder_row_inner][/fusion_builder_column]Related Posts
RNA sequencing reveals functional chimeric mRNAs in mammalian immunity
Atlas of the brain’s striatum could guide researchers to new drug treatments
Immune cells offer insights on billion-dollar virus
A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction
Dietary oxidized plant sterol shifts macrophage state to fuel aortic inflammation
Unlocking the past – new method helps gain insights into old tissue
Novel AI model trained on RNA-Seq data accurately detects key gene mutations and predicts biomarkers across 32 cancer types
Transcriptomic aging clock reveals age-related molecular patterns in opioid dependence
RNA sequencing helps predict stem cell transplant benefit in pediatric AML
Protein ‘switch’ determines whether liposarcoma cells will become aggressive
Precursor tRNAs sense temperature changes: heat stress-induced capped pre-tRNAs suppress protein synthesis
Ketamine increases neuroplasticity in female mice but not in males
Somatic mutations linked to vascular damage in progeria
Scientists map dormant cancer cells’ hideouts, opening new targets for treatment
Soluble signals released by neighboring cells direct how the human kidney is built
Genetics influence how cancer arises – and how it evolves
RNA-based testing uncovers extraordinary diversity in mutations driving lung cancer
Study offers new insights into why ex-smokers remain at elevated risk of lung disease
Learning the grammar of gene regulation
New findings could transform new treatment for rare brain tumor astroblastoma
Stay Connected
Submit a Post to the Blog
Recent Posts
Subscribe to the RNA-Seq Blog
RNA-Seq Products & Services