End-to-End Solutions Planned to Support Key Customer Applications With Increased Cost Flexibility on Long-Read Sequencing Systems PacBio a leading developer of high-quality, highly accurate sequencing solutions, today announced the commencement of a program intended to expand Multiplexed Arrays Sequencing (MAS-Seq) ...

Rodents are major reservoirs of pathogens responsible for numerous zoonotic diseases in humans and livestock. Assessing their microbial diversity at both the individual and population level is crucial for monitoring endemic infections and revealing microbial association patterns within reservoirs. Recently, ...

In ecological studies microbial diversity is nowadays mostly assessed via the detection of phylogenetic marker genes such as 16S ribosomal RNA. However, PCR amplification of these marker genes produces a significant amount of artificial sequences often referred to as chimeras. ...

Experimental designs that take advantage of high-throughput sequencing to generate datasets include RNA sequencing (RNA-seq), chromatin immunoprecipitation sequencing (ChIP-seq), sequencing of 16S rRNA gene fragments, metagenomic analysis and selective growth experiments. In each case the underlying data are similar and ...

Dr. Christopher Taylor, Assistant Professor, Department of Computer Science, University of New Orleans.

Regensburg researchers decode the step-by-step ribosome biosynthesis in archaea. Archaea are microscopic life forms that rank among the three...

 Characterization of microbial activity is essential to the understanding of the basic biology of microbial communities, as the function of a microbiome is defined by its biochemically active (“viable”) community members. Current sequence-based technologies can rarely differentiate microbial activity, ...

A sequencing-based solution can be utilised to determine infection clearance and microbiota recovery. Next, the researchers will apply the technique to investigate the coronavirus disease. Infectious diseases are caused by pathogenic viruses, bacteria, fungi or parasites. The treatment of bacterial ...

RNA sequencing is a powerful approach to quantify the genome-wide distribution of mRNA molecules in a population to gain deeper understanding of cellular functions and phenotypes. However, unlike eukaryotic cells, mRNA sequencing of bacterial samples is...

RNA extracted from bacterial species comprises up to 98 % of ribosomal RNAs (rRNA), preventing the in-depth analysis of RNAs of interest, particularly in the context of Next Generation Sequencing (RNA-Seq). Moreover, depletion of rRNA derived from multi-species bacterial communities ...