RNA is central to how cells function. Through the detailed study of RNA that combines molecular biology with advanced bioinformatics, Vicente Pelechano Garcia hopes to contribute to the development of a new generation of RNA-based treatment and diagnosis. Meet one of the new professors of Karolinska Institutet who will participate in this year’s installation ceremony at Aula Medica on 9 October.
What are you researching?
“My research focuses on understanding how RNA – the molecule that helps turn genetic information into proteins – controls the behaviour of cells. Every cell in our body contains the same DNA, but what makes cells different is how that DNA is read and interpreted. RNA plays a central role in this process, carrying instructions from the DNA to the cell’s protein-making machinery. In our lab, we study how RNA is made, processed, used and degraded, and how these processes affect everything from how cancer cells behave to the development of antibiotic resistance.”
Why is this important?
“If something goes wrong with RNA – if it is made incorrectly, processed in the wrong way, or degraded too quickly or too slowly – it can have serious consequences. Understanding RNA biology is therefore essential for designing better diagnostics and new treatments. The COVID-19 pandemic showed just how powerful mRNA vaccines can be as a medical tool.”
How are you going about this?
“We’re combining molecular biology with sequencing-based methods and advanced bioinformatics to study RNA at a detailed level. These techniques allow us to track RNA molecules from the moment they’re made to the moment they’re degraded, and to see how they’re being used and regulated under different conditions, such as when bacteria become resistant to antibiotics or cancer cells to treatment.”
What do you hope to achieve?
“We want our research to generate knowledge about the fundamental principles of life and to inspire practical applications. In the long run, we hope to contribute to a new generation of RNA-based diagnostics and treatments that can change how we treat many different diseases.”
Source – Karolinska Institutet
RNA is central to how cells function. Through the detailed study of RNA that combines molecular biology with advanced bioinformatics, Vicente Pelechano Garcia hopes to contribute to the development of a new generation of RNA-based treatment and diagnosis. Meet one of the new professors of Karolinska Institutet who will participate in this year’s installation ceremony at Aula Medica on 9 October.
What are you researching?
“My research focuses on understanding how RNA – the molecule that helps turn genetic information into proteins – controls the behaviour of cells. Every cell in our body contains the same DNA, but what makes cells different is how that DNA is read and interpreted. RNA plays a central role in this process, carrying instructions from the DNA to the cell’s protein-making machinery. In our lab, we study how RNA is made, processed, used and degraded, and how these processes affect everything from how cancer cells behave to the development of antibiotic resistance.”
Why is this important?
“If something goes wrong with RNA – if it is made incorrectly, processed in the wrong way, or degraded too quickly or too slowly – it can have serious consequences. Understanding RNA biology is therefore essential for designing better diagnostics and new treatments. The COVID-19 pandemic showed just how powerful mRNA vaccines can be as a medical tool.”
How are you going about this?
“We’re combining molecular biology with sequencing-based methods and advanced bioinformatics to study RNA at a detailed level. These techniques allow us to track RNA molecules from the moment they’re made to the moment they’re degraded, and to see how they’re being used and regulated under different conditions, such as when bacteria become resistant to antibiotics or cancer cells to treatment.”
What do you hope to achieve?
“We want our research to generate knowledge about the fundamental principles of life and to inspire practical applications. In the long run, we hope to contribute to a new generation of RNA-based diagnostics and treatments that can change how we treat many different diseases.”
Source – Karolinska Institutet
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RNA is central to how cells function. Through the detailed study of RNA that combines molecular biology with advanced bioinformatics, Vicente Pelechano Garcia hopes to contribute to the development of a new generation of RNA-based treatment and diagnosis. Meet one of the new professors of Karolinska Institutet who will participate in this year’s installation ceremony at Aula Medica on 9 October.
What are you researching?
“My research focuses on understanding how RNA – the molecule that helps turn genetic information into proteins – controls the behaviour of cells. Every cell in our body contains the same DNA, but what makes cells different is how that DNA is read and interpreted. RNA plays a central role in this process, carrying instructions from the DNA to the cell’s protein-making machinery. In our lab, we study how RNA is made, processed, used and degraded, and how these processes affect everything from how cancer cells behave to the development of antibiotic resistance.”
Why is this important?
“If something goes wrong with RNA – if it is made incorrectly, processed in the wrong way, or degraded too quickly or too slowly – it can have serious consequences. Understanding RNA biology is therefore essential for designing better diagnostics and new treatments. The COVID-19 pandemic showed just how powerful mRNA vaccines can be as a medical tool.”
How are you going about this?
“We’re combining molecular biology with sequencing-based methods and advanced bioinformatics to study RNA at a detailed level. These techniques allow us to track RNA molecules from the moment they’re made to the moment they’re degraded, and to see how they’re being used and regulated under different conditions, such as when bacteria become resistant to antibiotics or cancer cells to treatment.”
What do you hope to achieve?
“We want our research to generate knowledge about the fundamental principles of life and to inspire practical applications. In the long run, we hope to contribute to a new generation of RNA-based diagnostics and treatments that can change how we treat many different diseases.”
Source – Karolinska Institutet
Related Posts
Urine test may improve bladder cancer diagnosis and guide treatment decisions
Tracing 700 million years of cell evolution
RNA-Seq reveals a new way the developing heart controls its growth
The Human RNome Project Consortium seeks to publish first-ever complete sequence of the body’s RNA
Unmasking “zombie cells” in aging tissue with an AI-powered barcode
RNA variant imaging for cancer diagnosis
Autism-risk mutations reveal two opposing patterns of brain gene activity
Avoiding a sticky situation: how cells stop messenger RNAs from clumping together
RNA Sequencing identifies new tick-borne virus that causes flu-like illness
Worm’s radical transformation shows metamorphosis can change the functions of cells
RNA sequencing reveals functional chimeric mRNAs in mammalian immunity
Atlas of the brain’s striatum could guide researchers to new drug treatments
Immune cells offer insights on billion-dollar virus
A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction
Dietary oxidized plant sterol shifts macrophage state to fuel aortic inflammation
Unlocking the past – new method helps gain insights into old tissue
Novel AI model trained on RNA-Seq data accurately detects key gene mutations and predicts biomarkers across 32 cancer types
Transcriptomic aging clock reveals age-related molecular patterns in opioid dependence
RNA sequencing helps predict stem cell transplant benefit in pediatric AML
Protein ‘switch’ determines whether liposarcoma cells will become aggressive
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