Marlon Stoeckius of the NY Genome Center describes two recently developed applications that utilize oligo-antibody conjugates to enhance existing single cell RNA-seq platforms. CITE-seq, allows measurement of a potentially unlimited number of protein markers in parallel to transcriptomes and Cell Hashing, enables sample multiplexing, robust multiplet detection and super-loading of scRNA-seq platforms. Reagents for performing these assays, under the name TotalSeq™ are now available from BioLegend.