Single-cell RNA-Seq Gaining Steam

rna-seq 1CellBio Announces Custom Targeted Bead Program to Accelerate Next Phase in Single-Cell Analysis (4/18/2019)- 1CellBio today announced a new program to supply select customers with its proprietary inDrop™ hydrogel beads synthesized with custom primers that target user-specified transcripts. “This new program enables researchers to focus their sequencing depth on their genes of interest rather than the full transcriptome,” said Colin J.H. Brenan, PhD, Chief Executive Officer at 1CellBio. “We ...
rna-seq scFBA – integration of single-cell RNA-seq data into population models to characterize cancer metabolism (4/2/2019)- Metabolic reprogramming is a general feature of cancer cells. Regrettably, the comprehensive quantification of metabolites in biological specimens does not promptly translate into knowledge on the utilization of metabolic pathways. By estimating fluxes across metabolic pathways, computational models hold the promise to bridge this gap between data and biological functionality. These models currently portray the ...
rna-seq Single cell combinatorial indexing reveals a landscape of mammalian development (3/19/2019)- New technology enables single cell analysis of mouse embryonic development Scientists from Seattle and Berlin have published an atlas on mouse embryonic...
A component overlapping attribute clustering (COAC) algorithm for single-cell RNA sequencing data analysis and potential pathobiological implications (3/14/2019)- Recent advances in next-generation sequencing and computational technologies have enabled routine analysis of large-scale single-cell ribonucleic acid sequencing (scRNA-seq) data. However, scRNA-seq technologies have suffered from several technical challenges, including low mean expression levels...
rna-seq Single-cell transcriptomics enables reseachers to explore the hypothalamus one neuron at a time (3/13/2019)- A collaborative team from UConn Storrs and The Jackson Laboratory for Genomic Medicine characterized neuron diversity in the lateral hypothalamic area (LHA), a critical coordinator of fundamental...
rna-seq Revolutionizing immunology with single-cell RNA sequencing (2/26/2019)- The immune system is composed of a complex hierarchy of cell types that protect the organism against disease and maintain homeostasis. Identifying heterogeneity of immune cells is the...
rna-seq In general, agreement among scRNA-Seq data analysis tools in calling DE genes is not high (2/15/2019)- The analysis of single-cell RNA sequencing (scRNAseq) data plays an important role in understanding the intrinsic and extrinsic cellular processes in biological and biomedical research. One significant effort in this area is the detection of...
rna-seq Improved RNA data visualization method gets to the bigger picture faster (2/14/2019)- Like going from a pinhole camera to a Polaroid, a significant mathematical update to the formula for a popular bioinformatics data visualization method will...
rna-seq New microfluidics platform separates cell types for RNA sequencing (2/6/2019)- A team led by scientists at the Broad Institute, MIT, and Massachusetts General Hospital has developed a prototype device that uses microfluidics to sort cell types extracted from clinical samples for RNA sequencing. This platform allows us to isolate specific cell...
1CellBio and Partek Deliver Easy-to-use Single Cell Analysis Solution (1/28/2019)- 1CellBio and Partek Deliver Easy-to-use Single Cell Analysis Solution Powerful Single Cell Bioinformatics Solution in a Graphical User Interface LOUIS and CAMBRIDGE — 1/24/2019 — 1CellBio Inc. and Partek Incorporated have partnered to deliver a data analysis pipeline for the inDrop™ System for use within Partek® Flow® bioinformatics software. The pipeline allows users to pre-process ...

A slew of recent high profile papers and upcoming conferences highlight the growing interest in single-cell transcriptomics.