from GenomeWeb
NEW YORK (GenomeWeb) – In a study appearing online this week in the Proceedings of the National Academy of Sciences, Stanford University researcher Stephen Quake and colleagues presented results from a single-cell transcriptome sequencing study of human brain cells.
The team did single-cell RNA sequencing on almost 500 adult or fetal brain cells, plucked from cortical brain rain cellsregions. The resulting transcriptional sequences broadly clustered the cells of all of the brain’s main sub-types — from microglia and astrocytes to neurons. But they also revealed clusters that coincided with neuronal sub-populations that varied by location and developmental stage.
“These results lay the groundwork for the construction of a cellular map of the human brain that can be completed through the analysis of a larger number of cells from different anatomical regions of the brain,” Quake and co-authors wrote. (read more…)
from GenomeWeb
NEW YORK (GenomeWeb) – In a study appearing online this week in the Proceedings of the National Academy of Sciences, Stanford University researcher Stephen Quake and colleagues presented results from a single-cell transcriptome sequencing study of human brain cells.
The team did single-cell RNA sequencing on almost 500 adult or fetal brain cells, plucked from cortical brain rain cellsregions. The resulting transcriptional sequences broadly clustered the cells of all of the brain’s main sub-types — from microglia and astrocytes to neurons. But they also revealed clusters that coincided with neuronal sub-populations that varied by location and developmental stage.
“These results lay the groundwork for the construction of a cellular map of the human brain that can be completed through the analysis of a larger number of cells from different anatomical regions of the brain,” Quake and co-authors wrote. (read more…)
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from GenomeWeb
NEW YORK (GenomeWeb) – In a study appearing online this week in the Proceedings of the National Academy of Sciences, Stanford University researcher Stephen Quake and colleagues presented results from a single-cell transcriptome sequencing study of human brain cells.
The team did single-cell RNA sequencing on almost 500 adult or fetal brain cells, plucked from cortical brain rain cellsregions. The resulting transcriptional sequences broadly clustered the cells of all of the brain’s main sub-types — from microglia and astrocytes to neurons. But they also revealed clusters that coincided with neuronal sub-populations that varied by location and developmental stage.
“These results lay the groundwork for the construction of a cellular map of the human brain that can be completed through the analysis of a larger number of cells from different anatomical regions of the brain,” Quake and co-authors wrote. (read more…)
Related Posts
Worm’s radical transformation shows metamorphosis can change the functions of cells
RNA sequencing reveals functional chimeric mRNAs in mammalian immunity
Atlas of the brain’s striatum could guide researchers to new drug treatments
Immune cells offer insights on billion-dollar virus
A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction
Dietary oxidized plant sterol shifts macrophage state to fuel aortic inflammation
Unlocking the past – new method helps gain insights into old tissue
Novel AI model trained on RNA-Seq data accurately detects key gene mutations and predicts biomarkers across 32 cancer types
Transcriptomic aging clock reveals age-related molecular patterns in opioid dependence
RNA sequencing helps predict stem cell transplant benefit in pediatric AML
Protein ‘switch’ determines whether liposarcoma cells will become aggressive
Precursor tRNAs sense temperature changes: heat stress-induced capped pre-tRNAs suppress protein synthesis
Ketamine increases neuroplasticity in female mice but not in males
Somatic mutations linked to vascular damage in progeria
Scientists map dormant cancer cells’ hideouts, opening new targets for treatment
Soluble signals released by neighboring cells direct how the human kidney is built
Genetics influence how cancer arises – and how it evolves
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