Study Points to Utility of Targeted RNA Sequencing for Low-abundance Transcripts

from GenomeWeb

NEW YORK (GenomeWeb) – A team led by researchers from Australia’s Garvan Institute of Medical Research this week reported new data demonstrating the superiority of a targeted RNA sequencing method called “capture sequencing” (CaptureSeq) over standard RNA sequencing and qRT-PCR for detecting and quantifying genes with low and differential expression, which they say are particularly relevant for studies involving human disease.

The scientists also reported the use of CaptureSeq to quantify long non-coding RNAs (lncRNAs) and novel coding exons across 20 different human tissues, refining previous annotations and creating a new expression atlas.

CaptureSeq was developed in 2011 to enable the characterization of unannotated transcripts (read more…)



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