Recent advances in the genetic understanding of acute myeloid leukemia (AML) have improved clinical outcomes in pediatric patients. However, ∼40% of patients with pediatric AML relapse, resulting in a...
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About five years ago, it was shown that mutations in genes encoding splicing factors occur frequently in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Splicing, the process by which introns are removed from the pre-messenger RNA and ...
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Several outlier and subgroup identification statistics (OASIS) have been proposed to discover transcriptomic features with outliers or multiple modes in expression that are indicative of distinct biological processes or subgroups. Here, researchers from the St. Jude Children’s Research Hospital, Memphis borrow ...
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