Tag Archives: adenocarcinoma

Single-cell RNA sequencing identifies tumor subpopulations

rna-seq

Single-cell sequencing, which is used to detect clinically important tumor subpopulations, is necessary for understanding tumor heterogeneity. Here, researchers from Kangwon National University, Korea analyzed transcriptomic data obtained from 34 single cells from human lung adenocarcinoma (LADC) patient-derived xenografts (PDXs). ...

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The statistical universe is a single patient – pathway analysis from “N-of-1” RNA-Seq data

rna-seq

The emergence of precision medicine allowed the incorporation of individual molecular data into patient care. Indeed, DNA sequencing predicts somatic mutations in individual patients. However, these genetic features overlook dynamic epigenetic and phenotypic response to therapy. Meanwhile, accurate personal transcriptome ...

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