CLASS2 – accurate and efficient splice variant annotation from RNA-Seq reads

March 31, 2016 Leave a comment 4,095 Views

Next generation sequencing of cellular RNA is making it possible to characterize genes and alternative splicing in unprecedented detail. However, designing bioinformatics tools to accurately capture splicing variation has proven difficult. Current programs can find major isoforms of a gene ...

Penn Researchers Illuminate “Dark Side” of the Transcriptome

February 10, 2016 Leave a comment 2,574 Views

New approach to quantifying gene “read-outs” reveals important variations in protein synthesis and has implications for understanding neurodegenerative diseases PHILADELPHIA— A new way of mapping the “transcriptome” — the collection of RNA read-outs that are expressed by a cell’s active ...

Microarray analysis workhorse limma – now capable of differential expression and differential splicing analyses of RNA-Seq data

January 23, 2015 Leave a comment 13,085 Views

limma is an R/Bioconductor software package that provides an integrated solution for analysing data from gene expression experiments. It contains rich features for handling complex experimental designs and for information borrowing to overcome the problem of small sample sizes. Over ...

RNA-Seq Blog Transcriptome Research & Industry News

Tag Archives: alternatice splicing

CLASS2 – accurate and efficient splice variant annotation from RNA-Seq reads

Penn Researchers Illuminate “Dark Side” of the Transcriptome

Microarray analysis workhorse limma – now capable of differential expression and differential splicing analyses of RNA-Seq data

Learning to predict RNA sequence expressions from whole slide images

CRIC-seq – global profiling of in-situ RNA–RNA contacts associated with a specific RNA-binding protein

Novel machine-learning algorithm creates atlas of cancer with potential as universal diagnostic platform

Long noncoding RNA profiling may be effective for stratification in pediatric AML

spSeudoMap – cell type mapping of spatial transcriptomics using unmatched single-cell RNA-seq data

SoCube – an innovative end-to-end doublet detection algorithm for analyzing scRNA-seq data

Quantabio adds powerful bead booster chemistry to ultra-fast sparQ RNA-Seq HMR kit