Tag Archives: alzheimer’s disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia, affecting more than 5.8 million individuals in the U.S. Scientists have discovered some genetic variants that increase the risk for...

Nobody knows why people with Down syndrome inevitably get Alzheimer’s – but Sanford Burnham Prebys is one step closer to finding out. In the first...

In the brain of a person with Alzheimer’s disease, neurons degenerate and die, slowly eliminating memories and cognitive skills. However, not all neurons are impacted equally. Some types of neurons in certain brain regions are more susceptible, and even among ...

Next-generation sequencing (NGS) technology has become a powerful tool for dissecting the molecular and pathological signatures of a variety of human...

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder of the brain and the most common form of dementia among the elderly. The single-cell RNA-sequencing (scRNA-Seq) and...

Researchers at the University of California San Diego discovered that high blood levels of RNA produced by the PHGDH gene could serve as a biomarker...

With the realization that microglia play a key role in neurodegenerative conditions, scientists have profiled their transcription patterns to see how they change during disease. A study published...

Rate of RNA decay could be a key to breakdown in communication between neurons McGill University researchers have discovered a cellular mechanism that may contribute to the breakdown of communication between neurons in Alzheimer’s disease. Their study, published in Nature ...

Neuroscientists identify genetic changes in microglia in a mouse model of neurodegeneration and Alzheimer’s disease. Microglia, immune cells that act as the central nervous system’s damage sensors, have recently been implicated in Alzheimer’s disease. The cells, a type of macrophage ...

To identify circulating miRNA biomarkers for AD, researchers from Meiji Pharmaceutical University, Japan reanalyzed a publicly available small RNA-Seq dataset, composed of blood samples derived from 48 AD patients and 22 normal control (NC) subjects, by a simple web-based miRNA ...