Patient specific stem cell-derived motor neurons stained for the neuronal marker III-Tubulin (green) and the ALS-implicated protein TDP-43 (magenta). In this study, the authors determined that TDP-43...
Read More »New RNA Sequencing method for studying ALS more effectively
The neurodegenerative disease ALS causes motor neuron death and paralysis. However, long before the cells die, they lose contact with the muscles as their axons atrophy. Researchers at Karolinska...
Read More »RNA-Seq sheds light on motor neuron death in ALS
A new study from Crick researchers shows that collaboration can be easy when you are part of a culture that supports it. We caught up with the scientists involved to find out how working...
Read More »RNA-Seq reveals a novel therapeutic strategy for ALS treatment
Amyotrophic lateral sclerosis (ALS) is a fatal heterogeneous neurodegenerative disease that lacks effective treatment option. Researchers at Genervon Biopharmaceuticals hypothesized that the traditional single-target approach to treat neurodegenerative...
Read More »A new resource may help RNA researchers go long in ALS
The ALS Research Forum – A new genomic resource may help researchers unravel the role of key RNA-binding proteins in ALS. The atlas, developed at the Riken Institute in Yokohama, Japan, contains 27,919 long non-coding RNAs – including 19,175 potentially ...
Read More »Total RNA Sequencing reveals microbial communities in human blood and disease specific effects
An increasing body of evidence suggests an important role of the human microbiome in health and disease. Researchers at UCLA have developed a ‘lost and found’ pipeline, which examines high quality unmapped sequence reads for microbial taxonomic classification. Using this ...
Read More »Transcriptomics identifies genes and signaling pathways that may regulate neurodegeneration
Society for Experimental Biology and Medicine Massive elimination of neurons is a critical aspect of normal nervous system development but also represents a defining feature of neurodegenerative pathologies, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and amyotrophic lateral sclerosis. ...
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