Tag Archives: autism

UCLA researchers performed RNA sequencing on 40,000 cells to create a high-resolution single-cell gene expression atlas of developing human cortex, providing the first single-cell characterization of previously uncharacterized cell types, including human subplate neurons, comparisons with bulk tissue, and systematic ...

Genetic studies have identified many risk loci for autism spectrum disorder (ASD) although causal factors in the majority of cases are still unknown. Currently, known ASD risk genes are all protein-coding genes; however, the vast majority of transcripts in humans ...

Researchers find some neurons in the autistic brain preferentially express the copy of a gene inherited from one parent over the other. Many researchers have assumed that most cells express both copies of a gene equally. Studies in cultured cells ...

from Nature Reviews Neuroscience by Natasha Bray – Many genetic factors are thought to contribute to autism spectrum disorder (ASD); however, whether the effects of these factors converge on common functional pathways is not clear. Now, Geschwind and colleagues at ...

from Spectrum.com by Ann Griswold – A new tool provides speedy analysis of gene expression patterns in individual neurons from postmortem brain tissue. Researchers have used the method to compare the genetic signatures of more than 3,000 neurons from distant ...

Co-expression networks have been a useful tool for functional genomics, providing important clues about the cellular and biochemical mechanisms that are active in normal and disease processes. However, co-expression analysis is often treated as a black box with results being ...

from Healio by Amanda Oldt RNA sequencing of postmortem brain samples from patients with bipolar disorder identified dysregulation of G-protein coupled receptors, novel bipolar disorder genes and noncoding transcriptome. “In order to understand the role that coding and noncoding RNAs ...

(ASD) are a group of neurodevelopmental disorders with high heritability. Recent findings support a highly heterogeneous and complex genetic etiology including rare de novo and inherited mutations or chromosomal rearrangements as well as double or multiple hits. A team led ...

from SFARI.org by Michael Talkowski, James Gusella Measuring RNA expression from individual genes provides one route to novel insights in understanding human disorders such as autism. For example, it may reveal the impact of a genetic mutation on the gene ...