Adenosine to inosine (A-to-I) RNA editing is a post-transcriptional modification catalyzed by the ADAR (adenosine deaminase that acts on RNA) enzymes, which are ubiquitously expressed among metazoans. Technical requirements have limited systematic mapping of editing sites to a small number ...
Read More »ElemeNT – a computational tool for detecting core promoter elements
Core promoter elements play a pivotal role in the transcriptional output, yet they are often detected manually within sequences of interest. Here, researchers from Bar-Ilan University present 2 contributions to the detection and curation of core promoter elements within given ...
Read More »RNA-Seq provides first global analysis of regulated splicing alterations in cancer
Cancer is a complex disease that involves aberrant gene expression regulation. Discriminating the modified expression patterns driving tumor biology from the many that have no or little contribution is important for understanding cancer molecular basis. Recurrent deregulation patterns observed in ...
Read More »