A large number of genes has been implicated in neurodevelopmental disorders (NDDs) such as autism, developmental delays, intellectual disabilities and epilepsy, but it is difficult to determine how these genes, individually and as a group, contribute to...
Read More »RNA Sequencing gives new insights into formation of neurons in mammalian adult brain
A team of researchers at Baylor College of Medicine, the Texas Heart Institute and Texas Children’s Hospital has developed a powerful new approach to understand the formation of new neurons in the mammalian adult brain. Published in the journal...
Read More »ASHG – RNA Sequencing Can Improve Diagnostic Yield of Exome, Genome Tests
RNA sequencing can help improve the diagnostic rate of exome and genome sequencing-based tests for genetic disease, according to a new study presented at the American Society for Human Genetics' annual meeting in San Diego this week. Despite the success...
Read More »SalmonTE – An ultra-fast and scalable quantification pipeline for transposable elements from next generation sequencing data
Transposable elements (TEs) are DNA sequences which are capable of moving from one location to another and represent a large proportion (45%) of the human genome. TEs have functional roles in a variety of biological phenomena such as cancer, neurodegenerative ...
Read More »Comprehensive evaluation of RNA-seq quantification methods for linearity
Deconvolution is a mathematical process of resolving an observed function into its constituent elements. In the field of biomedical research, deconvolution analysis is applied to obtain single cell-type or tissue specific signatures from a mixed signal and most of them ...
Read More »MATQ-seq – effective detection of variation in single-cell transcriptomes
The development of single-cell RNA-seq has allowed the detection of gene expression at an anatomical resolution that is not accessible by bulk RNA-seq approaches. While single-cell RNA-seq methods have been successfully used to identify new cell types in complex tissues, ...
Read More »Patch-Seq – combines patch-clamp recording with single-cell RNA sequencing
Despite its importance, scientists still do not understand all of the different cell types that make up the brain. A group of researchers from Baylor College of Medicine (Drs. Andreas and Kimberley Tolias’ laboratories), the Karolinska Institutet (Dr. Rickard Sandberg’s ...
Read More »Baylor College of Medicine to use RNA-Seq for molecular characterization of tissue from NCI’s exceptional responders
from Genetic Engineering News The National Cancer Institute (NCI) led study will investigate the unique molecular indicators of tumors associated with cancer patients with excellent prognosis to drug therapies. The study will include participation from Baylor College of Medicine, Nationwide ...
Read More »Protein expression gets the heart pumping
HOUSTON – (April 22, 2014) – Most people think the development of the heart only happens in the womb, however the days and weeks following birth are full of cellular changes that play a role in the structure and function ...
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