Tag Archives: bipolar disorder

Recent studies have found a high genetic similarity of the psychiatric diseases schizophrenia and bipolar disorder, whose disease-specific changes in brain cells show an overlap of more than 70 percent. These changes affect gene expression, i.e., transcription of genes for ...

Our understanding of the pathophysiology of psychiatric disorders, including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD), lags behind other fields of medicine. The diagnosis and study of these disorders currently depend on...

Researchers have developed new single-cell sequencing methods that could be used to map the cell origins of various brain disorders, including Alzheimer’s, Parkinson’s, schizophrenia and bipolar disorder. By analyzing individual nuclei of cells from adult human brains, researchers at the ...

While bipolar disorder is one of the most-studied neurological disorders—the Greeks noticed symptoms of the disease as early as the first century—it’s possible that scientists have overlooked an important part of the brain for its source. Scientists from the Florida ...

An increasing body of evidence suggests an important role of the human microbiome in health and disease. Researchers at UCLA have developed a ‘lost and found’ pipeline, which examines high quality unmapped sequence reads for microbial taxonomic classification. Using this ...

from Healio by Amanda Oldt RNA sequencing of postmortem brain samples from patients with bipolar disorder identified dysregulation of G-protein coupled receptors, novel bipolar disorder genes and noncoding transcriptome. “In order to understand the role that coding and noncoding RNAs ...

Psychiatric disorders such as schizophrenia (SZ) and bipolar disorder (BP) are projected to lead the global disease burden within the next decade. Several lines of evidence suggest that epigenetic- or genetic-mediated dysfunction is frequently present in these disorders. To date, ...

from medwireNews By Eleanor McDermid Mol Psychiatry 2014; Advance online publication An RNA sequencing study of patients with bipolar disorder has shown altered expression of genes and transcripts, including those involved in neuroplasticity and circadian rhythms. Nirmala Akula (National Institute ...