Tag Archives: cancer

In cancer cells, genetic errors wreak havoc. Misspelled genes, as well as structural variations—larger-scale rearrangements of DNA that can encompass large chunks of chromosomes—disturb carefully balanced mechanisms that have evolved to regulate cell growth. Genes that are normally silent are...

Tumours in sea turtles may be able to be treated using cancer treatments available to humans. A study published in the journal Communications...

Novel biomarkers for pancreatic adenocarcinoma are urgently needed because of its poor prognosis. Here, by using The Cancer Genome Atlas (TCGA) RNA-seq data, researchers from the Huazhong University of...

Gene fusion is a chromosomal rearrangement event which plays a significant role in cancer due to the oncogenic potential of the chimeric protein generated through fusions. The chimeric protein produced as a result of fusion of genes often possesses oncogenic ...

n 1995, two University of Chicago-based cancer specialists suggested there was an intermediate state—somewhere between curable localized cancers and lethal widespread disease—for patients with metastatic cancer. Those physicians, Samuel...

A postdoctoral position is immediately available in the Hsieh Lab at the Fred Hutchinson Cancer Research Center. The core focus of the Hsieh Lab is to interrogate the mechanisms by which post-transcriptional gene regulation governs cancer cell behavior...

Study could help researchers target cancer-specific processes for cancer prevention or to develop treatments New research on bowel cancer has shown that every tumour is different, and that every cell within the tumour is also genetically unique. In the first ...

In early breast cancer (BC), five conventional biomarkers—estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER2), Ki67, and Nottingham histologic...

Current bioinformatics methods to detect changes in gene isoform usage in distinct phenotypes compare the relative expected isoform usage in phenotypes. These statistics model differences in isoform usage in...

RNA microarrays and RNA-seq are now standard technologies to study the transcriptional activity of cells. Most studies focus on tracking transcriptional changes caused by specific experimental conditions. Information referring to genes up- and...