RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection

May 13, 2020 Leave a comment 1,858 Views

Prion diseases and prion-like disorders, including Alzheimer’s disease and Parkinson’s disease, are characterized by gliosis and accumulation of misfolded aggregated host proteins. Ablating microglia in prion-infected brain by treatment with the colony-stimulating factor-1 receptor (CSF-1R) inhibitor, PLX5622, increased accumulation of ...

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RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection

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