TGen and HonorHealth investigators suggest this granular analysis could lead to better treatments for pancreatic cancer patients Led by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, and by HonorHealth Research and...
Read More »Probe-Seq – transcriptional profiling of specific cell types from heterogeneous tissue by RNA-based isolation
Recent transcriptional profiling technologies are uncovering previously-undefined cell populations and molecular markers at an unprecedented pace. While single cell RNA (scRNA) sequencing is an attractive...
Read More »Comet – combinatorial prediction of marker panels from single-cell transcriptomic data
Single-cell transcriptomic studies are identifying novel cell populations with exciting functional roles in various in vivo contexts, but identification of succinct gene marker panels for such populations remains a challenge. Researchers at the Dana-Farber...
Read More »New microfluidics platform separates cell types for RNA sequencing
A team led by scientists at the Broad Institute, MIT, and Massachusetts General Hospital has developed a prototype device that uses microfluidics to sort cell types extracted from clinical samples for RNA sequencing. This platform allows us to isolate specific cell...
Read More »RNA-Seq constructs atlas of brain blood vessels, provides fresh clues to brain diseases
Even though diseases of the brain vasculature are some of the most common causes of death in the West, knowledge of these blood vessels is limited. Now researchers from Uppsala University and Karolinska Institutet in Sweden present in the journal ...
Read More »RolyPoly – inferring relevant cell types for complex traits using single-cell gene expression
Previous studies have prioritized trait-relevant cell types by looking for an enrichment of genome-wide association study (GWAS) signal within functional regions. However, these studies are limited in cell resolution by the lack of functional annotations from difficult-to-characterize or rare cell ...
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