The functional study on circRNAs has been increasing in the past decade due to its important roles in micro RNA sponge, protein coding, the...
Read More »How much do you know about circRNA research? – II
The discovery of the novel protein-encoding function of circRNA and its role in clinical sciences. The circRNA field is relatively new – in the previous blog (https://www.rna-seqblog.com/how-much-do-you-know-about-circrna-research/), we got acquainted with the basic roles of circRNA, particularly with...
Read More »How much do you know about circRNA research?
circRNAs: uncovering the functions of novel non-coding sequences – from developmental biology to anti-cancer therapies Summary What is circRNA? (Research on the function of circRNA; research hotspots in life sciences and medicine) Circular RNAs (circRNAs) are a new class of ...
Read More »seekCRIT – detecting and characterizing differentially expressed circular RNAs using high-throughput sequencing data
Over the past two decades, researchers have discovered a special form of alternative splicing that produces a circular form of RNA. Although these circular RNAs (circRNAs) have garnered considerable...
Read More »New research identifies circulating RNA preeclampsia biomarkers
Researchers at Illumina and several universities have shown that sequencing circulating RNA (C-RNA) can detect molecular signals of preeclampsia in the blood. Published in Science Translational Medicine...
Read More »circRNAprofiler – an R-based computational framework for the downstream analysis of circular RNAs
Circular RNAs (circRNAs) are a newly appreciated class of non-coding RNA molecules. Numerous tools have been developed for the detection of circRNAs, however computational tools to perform downstream...
Read More »Closing the circle – current state and perspectives of circular RNA databases
Circular RNAs (circRNAs) are covalently closed RNA molecules that have been linked to various diseases, including cancer. However, a precise function and working mechanism are lacking for the larger majority. Following many different experimental and...
Read More »CIRCpedia v2: an updated database for comprehensive circular RNA annotation and expression comparison
Circular RNAs (circRNAs) from back-splicing of exon(s) have been recently identified to be broadly expressed in eukaryotes, in tissue- and species- specific manners. Although functions of most circRNAs...
Read More »Discovering circRNA-microRNA interactions from CLIP-Seq and RNA-Seq data
Circular RNAs (circRNAs) represent an abundant group of noncoding RNAs in eukaryotes and are emerging as important regulatory molecules in physiological and pathological processes. However, the precise mechanisms and functions of most of circRNAs remain largely unknown. In this chapter, ...
Read More »CSCD – a database for cancer-specific circular RNAs
Circular RNA (circRNA) is a large group of RNA family extensively existed in cells and tissues. High-throughput sequencing provides a way to view circRNAs across different samples, especially in various diseases. However, there is still no comprehensive database for exploring ...
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