Circular RNAs (circRNAs) act through multiple mechanisms via their sequence features to fine-tune gene expression networks. Due to overlapping sequences with linear cognates, identifying internal...
Read More »Cerina – systematic circRNA functional annotation based on integrative analysis of ceRNA interactions
Circular RNAs, a family of covalently circularized RNAs with tissue-specific expression, were recently demonstrated to play important roles in mammalian biology. Regardless of extensive research to predict...
Read More »Identification and characterization of circRNAs encoded by MERS-CoV, SARS-CoV-1 and SARS-CoV-2
The life-threatening coronaviruses MERS-CoV, SARS-CoV-1 and SARS-CoV-2 (SARS-CoV-1/2) have caused and will continue to cause enormous morbidity and mortality to humans. Virus-encoded noncoding RNAs are poorly understood in coronaviruses. Data mining of viral-infection-related RNA-sequencing data has resulted in the identification ...
Read More »A practical guide for circular RNA analysis: Steps, tips, and resources
Recent technological advances in RNA sequencing and analysis have allowed an increasingly thorough investigation of a previously unexplored class of transcripts, circular (circ)RNAs. Accumulating...
Read More »Ultrasensitive detection of circular RNA by accurate recognition of the specific junction site
Circular RNAs (circRNAs), as a class of newly emerging biomarkers, have shown to be associated with many fundamental life processes and diseases, especially cancer. However, various limitations in currently available detection methods have...
Read More »Circular RNA profiling by Illumina sequencing via template-dependent multiple displacement amplification
Circular RNAs (circRNAs) are newly discovered incipient non-coding RNAs with potential roles in disease progression in living organisms. Significant reports, since their inception, highlight the abundance...
Read More »Methods for annotation and validation of circular RNAs from RNA-Seq data
Circular RNAs are an emerging class of transcript isoforms created by unique back splicing of exons to form a closed covalent circular structure. While...
Read More »circlncRNAnet – An integrated web-based resource for mapping functional networks of long or circular forms of non-coding RNAs
Despite their lack of protein-coding potential, lncRNAs and circRNAs have emerged as key determinants in gene regulation, acting to fine-tune transcriptional and signaling output. These non-coding...
Read More »RNA-Seq Identifies Circular RNAs in Arabidopsis
Leaf growth and senescence are controlled by tight genetic factors involved regulation at multiple levels. Circular RNAs (circRNAs) have recently been reported as the microRNA sponge to accomplish corresponding regulatory roles. This study aims to explore the expression profile and ...
Read More »Quantifying circular RNA expression from RNA-seq data using model-based framework
Circular RNAs (circRNAs) are a class of non-coding RNAs that are widely expressed in various cell lines and tissues of many organisms. Although the exact function of many circRNAs is largely unknown, the cell type- and tissue-specific circRNA expression has ...
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