Tag Archives: circular RNA

High-throughput RNA sequencing methods coupled with specialized bioinformatic analyses have recently uncovered tens of thousands of unique circular (circ)RNAs, but their complete sequences, genes of origin and functions are largely unknown. Given that circRNAs lack free ends and are thus ...

Circular RNAs (circRNAs) are a class of non-coding RNAs that are widely expressed in various cell lines and tissues of many organisms. Although the exact function of many circRNAs is largely unknown, the cell type- and tissue-specific circRNA expression has ...

It has been known that circular RNAs are widely expressed in human tissues and cells, and play important regulatory roles in physiological or pathological processes. However, there is lack of comprehensively annotated human circular RNAs database. Now, researchers from Nanjing ...

Recent studies reveal an important role of non-coding circular RNA (circRNA) in the control of cellular processes. Because of differences in the organization of plant and mammal genomes, the sensitivity and accuracy of circRNA prediction programs using algorithms developed for ...

Analysis of RNA-seq data often detects numerous ‘non-co-linear’ (NCL) transcripts, which comprised sequence segments that are topologically inconsistent with their corresponding DNA sequences in the reference genome. However, detection of NCL transcripts involves two major challenges: removal of false positives ...

from Wired.com by Nick Stockton The California headquarters of Cofactor Genomics is a bright little bungalow a few blocks from downtown Mountain View. Floral vines abuzz with insects and hummingbirds partially obscure the patio and its two Adirondack chairs. Jarret ...

Cofactor Genomics has been awarded a $1.5 million Phase II Small Business Innovation Research (SBIR) grant by the National Institute on Drug Abuse (NIDA) at the National Institutes of Health. This award follows a successful phase I showing the performance ...

Recent studies reveal that circular RNAs (circRNAs) are a novel class of abundant, stable and ubiquitous noncoding RNA molecules in animals. A comprehensive detection of circRNAs from high-throughput transcriptome data is an initial and crucial step to study their biogenesis ...

Israeli-led research finds circular RNA puts brakes on gene expression, could cause degenerative disease from Times of Israeli by Andrew Tobin An Israeli-led research team has discovered how a mysterious circular type of genetic molecule is produced, and that might ...

August 2014, Cofactor Genomics has been awarded a grant by the National Institute of Mental Health (NIMH), an institute of the NIH, to develop a standardized enrichment kit and define the normal reference profile for circular RNAs (circRNA) in the nervous ...