Circular RNAs are an emerging class of transcript isoforms created by unique back splicing of exons to form a closed covalent circular structure. While...
Read More »A comprehensive overview and evaluation of circular RNA detection tools
Circular RNA (circRNA) is mainly generated by the splice donor of a downstream exon joining to an upstream splice acceptor, a phenomenon known as backsplicing. It has been reported that circRNA can function as microRNA (miRNA) sponges, transcriptional regulators, or ...
Read More »CIRI – de novo circular RNA identification
Recent studies reveal that circular RNAs (circRNAs) are a novel class of abundant, stable and ubiquitous noncoding RNA molecules in animals. A comprehensive detection of circRNAs from high-throughput transcriptome data is an initial and crucial step to study their biogenesis ...
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