Veranome Biosystems LLC announced today that it has entered a collaboration and licensing agreement with Cold Spring Harbor Laboratory (CSHL) that adds...
Read More »RNA-seq alignment – where methodological progress can still occur
Many tools are available for RNA-seq alignment and expression quantification, with comparative value being hard to establish. Benchmarking assessments often highlight methods' good performance, but are focused on either model data or fail to explain...
Read More »Envisagenics named winner of Innovate.AI competition
Envisagenics is the developer of SpliceCore, software that analyzes RNA sequencing (RNA-seq) data to accelerate RNA therapeutics discovery using innovative machine learning to identify new...
Read More »Direct measurement of nascent transcription explains some of our differences from other primates
Humans, chimps and monkeys have strikingly similar genomes. This data helps us understand differences across these primate species. It displays information
Read More »Breakout Labs Funds RNA-Seq Startup Envisagenics
Breakout Labs, the Thiel Foundation’s seed-stage fund for deep technology companies, announced its latest four investments, each propelling radical science and technology to improve human health. The new awards bring the total number of companies backed by Breakout Labs to ...
Read More »Quantitative approaches for investigating the spatial context of gene expression
The spatial information associated with gene expression is important for elucidating the context-dependent transcriptional regulation during development. Recently, high-resolution sampling approaches, such as RNA tomography or single-cell RNA-seq combined with fluorescence in situ hybridization (FISH), have provided indirect ways to ...
Read More »RNA-Seq reveals how gene network controls flower/fruit production
Cold Spring Harbor, NY — There is staggering diversity in the number of flowers produced by each of the 2,800 or so species of plants in the nightshade family, which includes economically important crops such as tomatoes, peppers, and potatoes. ...
Read More »Iso-Seq analysis of SMRT sequencing data produces most detailed maize transcriptome yet
Improvements in maize breeding are required to feed a growing population and will depend on a more complete understanding of global gene expression in the plant. In a new publication from Cold Spring Harbor Laboratory (CSHL), scientists produced the largest ...
Read More »Researchers use single-cell RNA-Seq to peer into the black box of co-expression networks
Co-expression networks have been a useful tool for functional genomics, providing important clues about the cellular and biochemical mechanisms that are active in normal and disease processes. However, co-expression analysis is often treated as a black box with results being ...
Read More »AuPairWise – a method to estimate RNA-seq replicability through co-expression
In addition to detecting novel transcripts and higher dynamic range, a principal claim for RNA-sequencing has been greater replicability, typically measured in sample-sample correlations of gene expression levels. Through a re-analysis of ENCODE data, researchers at Cold Spring Harbor Laboratory ...
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