Long noncoding RNAs (lncRNAs) play a key role in normal tissue differentiation and cancer development through their tissue-specific expression in the human transcriptome. Recent investigations of macromolecular interactions have shown that tissue-specific lncRNAs form base-pairing interactions with various mRNAs associated ...
Read More »miR-RACE – An Approach to Determine the Sequence of Computationally Identified miRNAs
Computational prediction of microRNAs (miRNAs) is one of the most important approaches in microRNA studies. While validation of the predicted microRNAs’ precise sequences is essential for further studies on their biogenesis, evolution, and functions, computational miRNA prediction methods, however, often ...
Read More »Computational prediction of miRNA genes from small RNA sequencing data
Next-generation sequencing now for the first time allows researchers to gage the depth and variation of entire transcriptomes. However, now as rare transcripts can be detected that are present in cells at single copies, more advanced computational tools are needed ...
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