Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets
Read More »Breakthrough technique for studying gene expression takes root in plants
An open-source RNA analysis platform has been successfully used on plant cells for the first time – an advance that could herald a new era of fundamental research and bolster efforts to engineer more efficient food and biofuel crop plants. The technology...
Read More »Elegant trick improves single-cell RNA sequencing
Droplet microfluidics has revolutionized single-cell RNA sequencing, offering a low-cost, high-throughput method for single-cell genomics. However, this method has been limited in its ability to capture complete RNA transcription information. Researchers at Cornell – led by Iwijn De Vlaminck...
Read More »A 3D printed droplet microfluidic device for single cell RNA-sequencing
New Device Enables Low-Cost Single-Cell Analysis and Leads to Identification of Fibroblast Subtypes in Rheumatoid Arthritis Patients Single-cell analysis holds enormous potential to study how individual cells influence disease and respond to treatment, but the lack of cost-effective and user-friendly ...
Read More »Inertial-ordering-assisted droplet microfluidics for high-throughput single-cell RNA-sequencing
Single-cell RNA-seq reveals the cellular heterogeneity inherent in the population of cells, which is very important in many clinical and research applications. Recent advances in droplet microfluidics have achieved the automatic isolation, lysis...
Read More »Taming the transcriptome with RNA-Seq
There’s a new RNA-seq in town. Although the old RNA-seq administered a certain rough justice, profiling RNA species well enough to support a relatively crude conception of the transcriptome, the new RNA-seq is more refined...
Read More »Correcting droplet-based single-cell RNA-seq experiments
Single-cell RNA-seq protocols provide powerful means for examining the gamut of cell types and transcriptional states that comprise complex biological tissues. Recently-developed approaches based on droplet microfluidics, such as inDrop or Drop-seq, use massively multiplexed barcoding to enable simultaneous measurements ...
Read More »Cell fixation and preservation for droplet-based single-cell transcriptomics
Recent developments in droplet-based microfluidics allow the transcriptional profiling of thousands of individual cells in a quantitative, highly parallel and cost-effective way. A critical, often limiting step is the preparation of cells in an unperturbed state, not altered by stress ...
Read More »Featured RNA-Seq Job – Research Assistant – Single-Cell RNA-Seq and Drop-Seq
Job LocationBoston, Massachusetts Req ID 20070BR Department Description: How does the brain control appetite and metabolism? What cell types, circuits, and signals underlie that control? These are some of the questions currently being addressed by a multi-disciplinary team of neuroscientists ...
Read More »Inaugural Certara Biomedical research scholarship awarded to post-doc using single cell RNA-Seq for ovarian cancer research
Postgraduate oncology research student and 2016 NIH Oxford-Cambridge Scholar David Morse’s mentor laboratory will receive the award Certara®, the leading provider of decision support technology and consulting services for optimizing drug development and improving health outcomes, today announced that the ...
Read More »