Tag Archives: drug targets

Penn Medicine study has implications for 100 top-selling US drugs, half of which target daily-oscillating genes PHILADELPHIA — A new effort mapping 24-hr patterns of expression for thousands of genes in 12 different mouse organs – five years in the making ...

To identify physiological targets of drugs and bioactive small molecules, researchers at The Rockefeller University developed an approach, named DrugTargetSeqR, which combines high-throughput sequencing, computational mutation discovery and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9-based genome editing. They applied this ...