N6-methyladenosine (m6A) is an abundant RNA modification that plays critical roles in RNA regulation and cellular function. Global m6A...
Read More »RNA-Seq reveals the color changing hogfish can “see” with its skin
Some animals are quick-change artists. Take the hogfish, a pointy-snouted reef fish that can go from pearly white to mottled brown to reddish in a...
Read More »RNA-Seq could help predict future outbreaks of emerging diseases
Durham, NC – Advances in genetic sequencing are uncovering emerging diseases in wildlife that other diagnostic tests can’t detect. In a study led by Duke University, researchers used a technique called whole-transcriptome sequencing to screen for blood-borne diseases in wild ...
Read More »Improved Transcript Isoform Discovery using ORF Graphs
High-throughput sequencing of RNA in vivo facilitates many applications, not the least of which is the cataloging of variant splice isoforms of protein-coding messenger RNAs. While many solutions have been proposed for reconstructing putative isoforms from deep sequencing data, these ...
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