The emergence of SARS-CoV-2 virus variants that are adding twists in the battle against COVID-19 highlight the need for better genomic monitoring of the virus, says Katia Koelle, associate professor of biology at Emory University. “Improved genomic surveillance of SARS-CoV-2 across ...
Read More »Mitigating the adverse impact of batch effects in sample pattern detection
It is well known that batch effects exist in RNA-seq data and other profiling data. Although some methods do a good job adjusting for batch effects...
Read More »RNA-Seq uncovers super cell that ‘locks up’ Ebola
Scars on the eyes of an Ebola survivor have led researchers to a ‘super cell’ that may have the potential to help contain the virus in future outbreaks. A paper published in Translational Vision Science & Technology today describes how retinal pigment ...
Read More »Featured RNA-Seq Job – Bioinformatics Analyst – R/Bioconductor proficiency highly preferred
Emory University (Atlanta, GA) Job Requisition ID: 61478BR Department: 821200:YRK: Microbiology & Immunology Operating Unit/Division: Yerkes National Primate Research Center Job Title: Bioinformatics Analyst Full/Part Time: Full-Time Regular/Temporary: Regular Job Description: Maintains software, hardware and the network in a bioinformatics ...
Read More »Featured Job – Experience working with RNA-Seq is a significant strength
Bioinformatics Analyst Emory University (Atlanta, GA) Job Title – Bioinformatics Analyst Job Requisition ID – 61478BR Operating Unit/Division – Yerkes National Primate Resear Department – 821200:YRK: Microbiology & Immunology Full/Part Time – Full-Time Regular/Temporary – Regular Job Description A full-time ...
Read More »Emory’s New RNA-seq Test for Neuromuscular Disorders Promises to Help Resolve Unknown Variants
from GenomeWeb NEW YORK (GenomeWeb) – Rare genetic diseases are increasingly diagnosed by gene sequencing panels or clinical exome tests, but the number of variants of unknown significance (VOUS or VUS) emerging from these tests is also growing. To help ...
Read More »Improve the statistical power of your cis-eQTL mapping for RNA-Seq data
Studies of expression quantitative trait loci (eQTLs) offer insight into the molecular mechanisms of loci that were found to be associated with complex diseases and the mechanisms can be classified into cis- and trans-acting regulation. At present, high-throughput RNA sequencing ...
Read More »PROPER – Comprehensive Power Evaluation for Differential Expression using RNA-seq
RNA-seq has become a routine technique in differential expression (DE) identification. Scientists face a number of experimental design decisions including the sample size. The power for detecting differential expression is affected by several factors including the fraction of DE genes, ...
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