Tag Archives: eqtls

Mapping eQTLs With RNA-Seq reveals a more comprehensive set of eQTLs and illuminates underlying molecular consequence missed by microarrays

Studies attempting to functionally interpret complex-disease susceptibility loci by GWAS and eQTL integration have predominantly employed microarrays to quantify gene-expression. RNA-Seq has the potential to discover a more comprehensive set of eQTLs and illuminate the underlying molecular consequence. Researchers from ...

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Calling genotypes from public RNA-sequencing data enables identification of genetic variants that affect gene-expression levels

RNA-sequencing (RNA-seq) is a powerful technique for the identification of genetic variants that affect gene-expression levels, either through expression quantitative trait locus (eQTL) mapping or through allele-specific expression (ASE) analysis. Given increasing numbers of RNA-seq samples in the public domain, ...

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Calling genotypes from public RNA-sequencing data enables identification of genetic variants that affect gene-expression levels

rna-seq

Given increasing numbers of RNA-seq samples in the public domain, researchers at the University of Groningen studied to what extent expression quantitative trait loci (eQTLs) and allele-specific expression (ASE) can be identified in public RNA-seq data while also deriving the ...

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