MicroRNAs (miRNAs) are small non-coding RNA molecules that play a key role in gene expression regulation. They have critical functions in various biological processes and their involvement in disease biology is well documented. Several measurement platforms have been developed to ...
Read More »RNA-Seq reveals distinct features of exosomal small RNA
Functional biomolecules, including small noncoding RNAs (ncRNAs), are released and transmitted between mammalian cells via extracellular vesicles (EVs), including endosome-derived exosomes. The small RNA composition in cells differs from exosomes, but underlying mechanisms have not been established. Researchers from the ...
Read More »The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling
Despite an enormous interest in the role of extracellular vesicles, including exosomes, in cancer and their use as biomarkers for diagnosis, prognosis, drug response and recurrence, there is no consensus on dependable isolation protocols. Now, researchers at Ghent University Hospital ...
Read More »Analysis of the RNA content of the exosomes derived from blood serum and urine and its potential as biomarkers
Exosomes are tiny vesicles (30-150 nm) constantly secreted by all healthy and abnormal cells, and found in abundance in all body fluids. These vesicles, loaded with unique RNA and protein cargo, have a wide range of biological functions, including cell-to-cell ...
Read More »Extracellular Biomarkers Summit
Cambridge Healthtech Institute’s Extracellular Biomarkers Summit, the newest addition to their biomarker and diagnostics portfolio will be held March 16-18, 2015 in Cambridge, MA. The four-track event merges the well-established microRNA as Biomarkers and Diagnostics Conference with focused discussions on ...
Read More »Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood
Next-generation deep sequencing (NGS) has provided the ability to profile miRNA in biological fluids making this approach a viable screening tool to detect miRNA biomarkers. However, collection and handling procedures of blood needs to be greatly improved for miRNA analysis ...
Read More »Next Generation Sequencing: Research to Clinic Conference
SELECTBIO is hosting its Next Generation Sequencing: Research to Clinic Conference to bring together delegates from around the world focusing on technology development, informatics/data analysis, and applications of next generation sequencing (NGS) in various research fields and the migration of ...
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