Tag Archives: FISSEQ

ReadCoor, Inc. today announced a multi-year grant from the Bill & Melinda Gates Foundation to apply their proprietary spatial sequencing technology to understand causes of childhood mortality. With this funding, ReadCoor will develop powerful methods using its FISSEQ platform – ...

ReadCoor, Inc., today announced completion of an oversubscribed $23 million Series A financing round and its concurrent launch from Harvard University’s Wyss Institute for Biologically Inspired Engineering. ReadCoor will commercialize the Wyss Institute’s FISSEQ (fluorescent in situ sequencing) technology. FISSEQ ...

The Wyss Institute for Biologically Inspired Engineering at Harvard University recently announced a cross-institutional consortium to map neural circuits within the brain to improve understanding of neuropathological disorders. The consortium will be conducted under a $21 million contract from the ...

RNA-sequencing (RNA-seq) measures the quantitative change in gene expression over the whole transcriptome, but it lacks spatial context. In contrast, in situ hybridization provides the location of gene expression, but only for a small number of genes. Here researchers from ...

from Genetic Engineering News by Anton Simeonov, Ph.D. This literature review highlights a study led by George Church describing FISSEQ, or fluorescent in situ RNA sequencing. Methods such as fluorescence in situ hybridization (FISH) allow gene expression to be observed ...

Writing in Science, Lee et al. report an exciting first step toward combining some of the best aspects of both methods to sequence RNA in single cells in situ. Their approach, called fluorescence in situ RNA sequencing (FISSEQ), effectively treats ...

from Biotechniques by Jeffrey M. Perkel, PhD By combining technologies, a new method reports both the expression and localization of thousands of RNA transcripts simultaneously. How will this approach change the way we see gene expression? Find out… When researchers ...

Fluorescent in situ sequencing from Wyss Institute on Vimeo. In biology, as in real estate, location matters. Working copies of active genes — called messenger RNAs or mRNAs — are positioned strategically throughout living tissues, and their location often helps ...