Tag Archives: Fred Hutchinson Cancer Research Center

MAST – a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data


Single-cell transcriptomics reveals gene expression heterogeneity but suffers from stochastic dropout and characteristic bimodal expression distributions in which expression is either strongly non-zero or non-detectable. Researchers at the Fred Hutchinson Cancer Research Center propose a two-part, generalized linear model for ...

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