Tag Archives: Garvan Institute of Medical Research

Nanopore sequencing enables direct measurement of RNA molecules without conversion to cDNA, thus opening the gates to a new era for RNA biology...

Fusion genes are a major cause of cancer. Their rapid and accurate diagnosis can inform clinical action, but current molecular diagnostic assays are restricted in resolution and throughput...

The human transcriptome is so large, diverse, and dynamic that, even after a decade of investigation by RNA sequencing (RNA-seq), we have yet to resolve its true dimensions. RNA-seq suffers from an expression-dependent bias that impedes characterization of low-abundance transcripts. ...

RNA sequencing (RNA-seq) can be used to assemble spliced isoforms, quantify expressed genes and provide a global profile of the transcriptome. However, the size and diversity of the transcriptome, the wide dynamic range in gene expression and inherent technical biases ...

The majority of the human genome is differentially expressed across a wide dynamic range to produce a spectrum of protein-coding and noncoding RNAs, generating a transcriptome of unexpected scale and complexity. These features present a challenge for gene-expression profiling with ...

from GenomeWeb NEW YORK (GenomeWeb) – A team led by researchers from Australia’s Garvan Institute of Medical Research this week reported new data demonstrating the superiority of a targeted RNA sequencing method called “capture sequencing” (CaptureSeq) over standard RNA sequencing ...