Tag Archives: gene fusions

A new generation of tools that identify fusion genes in RNA-seq data is limited in either sensitivity and or specificity. To allow further downstream analysis and to estimate performance, predicted fusion genes from different tools have to be compared. However, ...

from Fred Hutch News by J Herman Acute myeloid leukemia (AML) affects hematopoietic progenitor and/or stem cells by altering key signaling pathways involved in differentiation, resulting in the clonal expansion of highly proliferative immature hematopoietic cells. When AML patient samples ...

  RNA-seq provide much more information than gene expression microarrays. In additional to gene expressions, it provides informa8on for: alternative splicing – structural changes of genes: Gene fusion. new genes/exons. splicing efficiency

The extraordinary success of imatinib in the treatment of BCR-ABL1 associated cancers underscores the need to identify novel functional gene fusions in cancer. RNA sequencing offers a genome-wide view of expressed transcripts, uncovering biologically functional gene fusions. Although several bioinformatics ...

SAN CARLOS, Calif.–(BUSINESS WIRE)–NuGEN Technologies, Inc., a market leader in the development of solutions for Next Generation Sequencing (NGS) applications, has announced the release of a novel targeted enrichment method that, in a single assay, will detect all possible fusion ...

Poster – A50 Gene expression analyses of RNA-Sequencing data across multiple cancers to identify Basal-like cancer subtypes Kevin Thompson, Mayo Clinic, United States Xiaojia Tang, Mayo Clinic, United States Jason Sinwell, Mayo Clinic, United States Peter Vedell, Mayo Clinic, United ...

Chromosome rearrangements that result in gene fusions have important roles in the initial steps of tumorigenesis, especially in leukemias and lymphomas, but the biological and clinical impact of gene fusions in common solid tumors are less understood. Researchers at the ...