Tag Archives: genome Biology

By studying the genomes of fruit flies, scientists from the Zaugg and Furlong groups at EMBL Heidelberg have identified a set of genomic features that can predict how much the expression of a gene varies between individuals in a species. Their...

from On Biology by Fritz Sedlazeck Read mapping is the process of aligning short sequences (also known as ‘reads’) to a reference genome or a de novo assembly. It is a major analysis step in nearly every Next Generation Sequencing ...

CINCINNATI – Researchers at Cincinnati Children’s Hospital Medical Center have developed a user-friendly, integrated platform for analyzing the transcriptomic and epigenomic “big data.” Reporting their platform in Genome Biology, scientists say that the new platform–called BioWardrobe–could help biomedical researchers answer ...

from Medical Xpress Sequencing RNA, not just DNA, could help doctors predict how prostate cancer tumors will respond to treatment, according to research published in the open access journal Genome Biology. Because a tumor’s RNA shows the real time changes ...

Numerous high-throughput sequencing studies focus on detecting conventionally spliced mRNAs in RNA-seq data. However, non-standard RNAs arising through gene fusion, circularization, or trans-splicing are often neglected. Researchers from the University Leipzig, Germany introduce a novel, unbiased algorithm to detect splice ...