Improved haplotype inference by exploiting long-range linking and allelic imbalance in RNA-seq datasets

September 17, 2020 Leave a comment 1,908 Views

Haplotype reconstruction of distant genetic variants remains an unsolved problem due to the short-read length of common sequencing data. Here, MIT researchers introduce HapTree-X, a probabilistic...

Recommendations for Accurate Resolution of Gene and Isoform Allele-Specific Expression in RNA-Seq Data

May 18, 2015 Leave a comment 6,960 Views

Genetic variation modulates gene expression transcriptionally or post-transcriptionally, and can profoundly alter an individual’s phenotype. Measuring allelic differential expression at heterozygous loci within an individual, a phenomenon called allele-specific expression (ASE), can assist in identifying such factors. Massively parallel DNA ...

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Tag Archives: haplotypes

Improved haplotype inference by exploiting long-range linking and allelic imbalance in RNA-seq datasets

Recommendations for Accurate Resolution of Gene and Isoform Allele-Specific Expression in RNA-Seq Data

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Advancements in genome sequencing propel global RNA sequencing market growth to 2030