Reversing scar tissue after a heart attack to create healthy heart muscle: this would be a game-changer in the field of cardiology and regenerative medicine. In the lab, scientists have shown it’s possible to change fibroblasts (scar tissue cells) into ...
Read More »Harvard researchers use scRNA-Seq to create temporal and spatial atlas of developing mouse heart
from Harvard Medical School by Stephanie Dutchen – It’s not simple, making a heart. In the womb, the organ begins as a tube, sprouts bead-like lumps, folds in on itself and eventually morphs into the more familiar-looking four-chambered structure. But ...
Read More »RNA-Seq reveals the mechanisms of transcription regulation during heart development
Dysregulation of transcription is associated with the pathogenesis of cardiovascular diseases, including congenital heart diseases and heart failure. However, it remains unclear how transcription factors regulate transcription in the heart and which genes are associated with cardiovascular diseases in humans. ...
Read More »MIRPIPE – quantification of microRNAs in niche model organisms
MicroRNAs represent an important class of small non-coding RNAs regulating gene expression in eukaryotes. Present algorithms typically rely on genomic data to identify miRNAs and require extensive installation procedures. Niche model organisms lacking genomic sequences cannot be analyzed by such ...
Read More »Protein expression gets the heart pumping
HOUSTON – (April 22, 2014) – Most people think the development of the heart only happens in the womb, however the days and weeks following birth are full of cellular changes that play a role in the structure and function ...
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