Hierarchical analysis of RNA-Seq reads improves the accuracy of allele-specific expression

February 16, 2018 Leave a comment 7,430 Views

Allele-specific expression (ASE) refers to the differential abundance of the allelic copies of a transcript. RNA sequencing (RNA-Seq) can provide quantitative estimates of ASE for genes with transcribed polymorphisms. When short-read sequences are aligned to a diploid transcriptome, readmapping ambiguities ...

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