A novel technique that isolates individual gut cells from mice with intestinal parasites may yield new insights on the immune response to these infections. Intestinal parasites are a serious threat to both humans and livestock in large parts of Africa...
Read More »Revolutionizing immunology with single-cell RNA sequencing
The immune system is composed of a complex hierarchy of cell types that protect the organism against disease and maintain homeostasis. Identifying heterogeneity of immune cells is the...
Read More »quanTIseq – quantifying immune contexture of human tumors
quanTIseq is the first computational pipeline for the quantification of Tumor-infiltrating Immune cells from raw RNA-seq data and images of haematoxylin and eosin (H&E)-stained tissue...
Read More »RNA-Seq reveals immune cells mistake heart attacks for viral infections
A study led by Kevin King, a bioengineer and physician at the University of California San Diego, has found that the immune system plays a surprising role in the aftermath of heart attacks. The research could lead to new therapeutic ...
Read More »Profiling RNA-Seq at multiple resolutions markedly increases the number of causal eQTLs
Genome-wide association studies have identified hundreds of risk loci for autoimmune disease, yet only a minority (~25%) share genetic effects with changes to gene expression (eQTLs) in immune cells. RNA-Seq based quantification at whole-gene resolution, where abundance is estimated by ...
Read More »Researchers use single-cell sequencing to understand how cells age
Researchers from the European Bioinformatics Institute (EMBL-EBI), University of Cambridge, the Wellcome Trust Sanger Institute and the Cancer Research UK-Cambridge Institute (CRUK-CI) have shed light on a long-standing debate about why the immune system weakens with age. Their findings, published ...
Read More »New subgroups of ILC immune cells discovered through single-cell RNA sequencing
Innate lymphoid cells (ILCs) are a group of immune cells that have only relatively recently been discovered in humans. Most of current knowledge about ILCs stems from animal studies of e.g. inflammation or infection in the gastrointestinal tract. There is ...
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