dsRNA is the genetic material of important viruses and a key component of RNA interference-based immunity in eukaryotes. Previous studies have noted difficulties in determining the sequence of dsRNA...
Read More »Researchers combine CRISPR gene editing and single cell genomic profiling
A new combined method may finally give scientists a tool fine enough to probe life’s most nuanced processes What combinations of mutations help cancer cells survive? Which cells in the brain are involved in the onset of Alzheimer’s? How do ...
Read More »RNA-Seq reveals shortcomings of experimentation models
Microglia are resident myeloid cells in the CNS that are activated by infection, neuronal injury, and inflammation. Established BV2 microglial cell lines have been the primary in vitro models used to study neuroinflammation for more than a decade because they ...
Read More »Single-Cell RNA Sequencing Study Reveals New Innate Lymphoid Cell Subpopulations
NEW YORK (GenomeWeb) – Using single-cell RNA sequencing to uncover transcriptional clusters, a Swedish team reporting in Nature Immunology has identified new sub-populations within at least one group of innate lymphoid cells (ILC), the diverse group of immune cells tasked ...
Read More »Researchers use RNA-Seq to understand bleaching of caribbean reef-building corals
Climate change-driven coral disease outbreaks have led to widespread declines in coral populations. Early work on coral genomics established that corals have a complex innate immune system, and whole-transcriptome gene expression studies have revealed mechanisms by which the coral immune ...
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