Using single-cell RNA sequencing data from primary cells to derive insights into genetic and transcriptional processes

October 3, 2017 Leave a comment 5,995 Views

As organisms age, cells accumulate genetic and epigenetic errors that eventually lead to impaired organ function or catastrophic transformation such as cancer. Because aging reflects a stochastic process of increasing disorder, cells in an organ will be individually affected in ...

Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes

January 26, 2016 Leave a comment 9,131 Views

Highlights Defined open chromatin regions in sorted human α- and β-cells using ATAC-seq. Detected type 2 diabetes-associated risk loci in human α- and β-cell open chromatin. Classified human α- and β-cell-specific transcripts using mRNA-seq. Discovered novel ...

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Using single-cell RNA sequencing data from primary cells to derive insights into genetic and transcriptional processes

Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes

Voltage-Seq – all-optical voltage imaging-guided postsynaptic single-cell transcriptome profiling

Researchers identify three genes associated with neurodevelopmental disorders

Fragment-Seq – local tissue microenvironments at single-cell resolution

snHH-Seq – pan-cancer single-nucleus total RNA sequencing

Optimised RNA extraction method unlocks tough tissues for aquaculture research

dsRID – in silico identification of dsRNA regions using long-read RNA-seq data

FUN-PROSE – predicting the response of fungal genes