Through integration of RNA-sequencing data with association study findings, researchers identified ERBB2, TP53 and THOP1 as new candidate genes in the pathogenesis of rheumatoid arthritis. In the blood cells of five patients newly diagnosed with rheumatoid arthritis (RA), seven patients ...
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RNA-sequencing of single-cells enables characterization of transcriptional heterogeneity in seemingly homogenous cell populations. In this study, reseachers from the Karolinska Institute propose and apply a novel method, ISOform-Patterns (ISOP), based on mixture modeling, to characterize the expression patterns of pairs ...
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Understanding the normal state of human tissue transcriptome profiles is essential for recognizing tissue disease states and identifying disease markers. Recently, the Human Protein Atlas and the FANTOM5 consortium have each published extensive transcriptome data for human samples using Illumina-sequenced ...
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