Tag Archives: liquid biopsy

RNA-Seq of serum microRNA signatures as liquid biopsies

MicroRNAs (miRNAs) released into the peripheral circulation upon cellular injury have shown a promise as a new class of tissue-specific biomarkers. Researchers from Maastricht University were first to demonstrate that next-generation sequencing analysis of serum from human subjects with acetaminophen-induced ...

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RNA is DNA in action

rna-seq

By Wallace Ravven – Losing a breast or a lung to cancer leaves a scar, both physical and emotional. But even a biopsy to determine if a tumor is cancerous, or to track a tumor’s response to drugs, brings short-term ...

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Recommendations for differential expression analysis and biomarker discovery small RNA-Seq experiments in an age of liquid biopsies

rna-seq

Small RNA-Seq has emerged as a powerful tool in transcriptomics, gene expression profiling and biomarker discovery. Sequencing cell-free nucleic acids, particularly microRNA (miRNA), from liquid biopsies additionally provides exciting possibilities for molecular diagnostics, and might help establish disease-specific biomarker signatures. ...

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RNA-seq for blood-based pan-cancer diagnostics

rna-seq

from Nature Reviews Genetics by Liesbet Lieben A systemic, minimally invasive diagnostic test to determine whether an individual has cancer could greatly improve cancer prognosis by facilitating early diagnosis and improving monitoring. However, the use of blood-based ‘liquid biopsies’ is ...

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