Small RNA-Seq has emerged as a powerful tool in transcriptomics, gene expression profiling and biomarker discovery. Sequencing cell-free nucleic acids, particularly microRNA (miRNA), from liquid biopsies additionally provides exciting possibilities for molecular diagnostics, and might help establish disease-specific biomarker signatures. ...
Read More »UCSF Researchers Discover that Deep Sequencing is Overkill for Many Applications
Ability to Extract Patterns From ‘Low Resolution’ Data Means Deep Sequencing is Overkill for Many Applications, Researchers Say New research by UCSF scientists could accelerate – by 10 to 100-fold – the pace of many efforts to profile gene activity, ...
Read More »USC patient RNA-Seq data shows potential of ANGLE’s Parsortix liquid biopsy for metastatic breast cancer screening
ANGLE plc , the specialist medtech company, has announced that the results of the University of Southern California (USC) Norris Comprehensive Cancer Center’s ongoing work with ANGLE’s Parsortix system have demonstrated the potential for the use of Parsortix as a ...
Read More »Minimally invasive genomic and transcriptomic profiling of visceral cancers by next-generation sequencing of circulating exosomes
The ability to perform comprehensive profiling of cancers at high resolution is essential for precision medicine. Liquid biopsies using shed exosomes provide high-quality nucleic acids to obtain molecular characterization, which may be especially useful for visceral cancers that are not ...
Read More »Big Industry News – Thermo to buy Affy – Illumina launches liquid biopsy startup
Reuters – Thermo Fisher to buy Affymetrix for $1.3 billion Thermo Fisher Scientific Inc (TMO.N), the world’s largest maker of scientific instruments, said it agreed to buy Affymetrix Inc (AFFX.O) for $1.3 billion in cash, beefing up its genetic analysis ...
Read More »RNA-seq for blood-based pan-cancer diagnostics
from Nature Reviews Genetics by Liesbet Lieben A systemic, minimally invasive diagnostic test to determine whether an individual has cancer could greatly improve cancer prognosis by facilitating early diagnosis and improving monitoring. However, the use of blood-based ‘liquid biopsies’ is ...
Read More »RNA-Seq of tumor platelets may diagnose and classify cancer, identify treatment strategies
Platelet RNA may provide easily accessible ‘liquid biopsy’ for many types of tumor Analysis of tumor RNA carried in platelets – blood components best known for their role in clotting – may prove to be more useful than other “liquid ...
Read More »Studies Presented at American Transplant Congress Describe Validation of RNA Sequencing for Post-Transplant Management of Kidney Graft Recipients
Studies by the scientific founders of Transplant Genomics Inc. (TGI) to be presented at the upcoming American Transplant Congress (ATC) May 2–6 in Philadelphia demonstrate validation of the company’s tests to support management of kidney transplant recipients. The tests are ...
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