Shotgun proteomics utilizes a database search strategy to compare detected mass spectra to a library of theoretical spectra derived from reference genome information. As such, the robustness of proteomics results is contingent upon the completeness and accuracy of the gene ...
Read More »Single-cell RNA-Seq analysis aids researchers in the bioengineering of 3D liver tissues
Scientists discover that three-dimensional liver buds grown in a dish from stem cells mimic the molecular signatures observed during the natural development of human liver An international team of researchers led by Barbara Treutlein of the Max Planck Institute for ...
Read More »RNA-Seq reveals the multilineage communication that regulates human liver bud development from pluripotency
Conventional two-dimensional differentiation from pluripotency fails to recapitulate cell interactions occurring during organogenesis. Three-dimensional organoids generate complex organ-like tissues; however, it is unclear how heterotypic interactions affect lineage identity. Here researchers from the Max Planck Institute for Evolutionary Anthropology use ...
Read More »RNA-Seq Reveals Neonatal-to-Adult Liver Maturation Depends on Alternative Splicing
from Genetic Engineering News When a baby is born, many of its tissues are still only partly formed. They need to be further developed before they are capable of performing adult functions. In general, neonatal-to-adult tissue remodeling is poorly understood, ...
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