RNA-Seq Blog Transcriptome Research & Industry News
In a paper in Cell Reports, Anindya Dutta, M.D., Ph.D., and colleagues detail the first structure-function study of a long non-coding RNA...
Read More »Distinct structural domains in MUNC long non-coding RNA regulate gene expression
lncExplore – a database of pan-cancer analysis and systematic functional annotation for lncRNAs from RNA-sequencing data
Researchers utilized transcriptomic sequencing data to systematically observe and identify lncRNAs and their potential functions from 5034 The Cancer Genome Atlas RNA-seq datasets covering 24 cancers...
Read More »How much do you know about circRNA research?
circRNAs: uncovering the functions of novel non-coding sequences – from developmental biology to anti-cancer therapies Summary What is circRNA? (Research on the function of circRNA; research hotspots in life sciences and medicine) Circular RNAs (circRNAs) are a new class of ...
Read More »Non-coding RNA, splicing regulators and RNA promoters: an insight into the molecular basis of colorectal cancer
Colorectal cancer (CRC) is considered as a significant cause of death among cancer-related mortality rates [1]. The guidelines promoted by different medical associations keep pushing and promoting effective screening programs, which have increased the early diagnosis of CRC and vastly ...
Read More »lncEvo – automated identification and conservation study of long noncoding RNAs
Long noncoding RNAs represent a large class of transcripts with two common features: they exceed an arbitrary length threshold of 200 nt and are...
Read More »Sperm long noncoding RNAs are active in zygotic genome activation and aberrantly expressed in multiple cancers
For long, sperm considered a passive vehicle, merely transmitting the paternal genome into oocyte during fertilization. Contrary to the prevailing view on sperm, Prof. Chandrasekhar kanduri lab and the team have shown that sperm-specific lncRNAs carrying distinct chromatin patterns are ...
Read More »Novel role for an RNA molecule found in the blood vessel wall may have implications for chronic vascular disease states and aging
Investigators from Brigham and Women’s Hospital have made a potentially exciting discovery by jumping into the abyss of the dark side of the genome. Once dismissed as “junk DNA,” roughly 75 percent of the human genome do not code for ...
Read More »Algorithms for identifying new “cancer genes”
It is estimated that the number of cancer cases worldwide will double by 2040. This makes the search for genes that cause cancer even more important. A team of researchers from the...
Read More »RNAsamba: long-noncoding RNA identification using a neural network classification model
The advent of high-throughput sequencing technologies made it possible to obtain large volumes of genetic information, quickly and inexpensively. Thus, many efforts are devoted to unveiling the biological roles of genomic elements, being the distinction between protein-coding and long non-coding ...
Read More »Machine learning-based annotation of long noncoding RNAs using PLncPRO
Long noncoding RNAs (lncRNAs) are noncoding RNAs with transcript length more than 200 nucleotides. Although poorly conserved, lncRNAs are expressed across diverse species, including plants and animals, and are known to be involved in...
Read More »